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tamoxifen CCO Formulary - June 2017 pathways to 4-hydroxytamoxifen or N-desmethyltamoxifen, then to endoxifen .
tamoxifen Tamoxifen is an inhibitor of   p-glycoprotein .
Active metabolites N-desmethyltamoxifen, 4-hydroxytamoxifen, Inactive metabolites tamoxifen Secreted in bile, undergoes enterohepatic circulation, 65% of the dose slowly   excreted in feces over 2 weeks, mainly as polar conjugates .
Parent drug: 5-7 days  N-desmethyltamoxifen: 9-14 days C - Indications and Status Health Canada Approvals: tamoxifen Adjuvant treatment of breast cancer (estrogen receptor positive tumours) in women Treatment of hormone responsive locally advanced or metastatic breast cancer in women Gynecological cancers (endometrial, ovarian) D - Adverse Effects Emetogenic Potential:   Not applicable  Extravasation Potential:   Not applicable Any use of the information is subject, at all times, to CCO’s Terms and Conditions .
CCO Formulary - June 2017 SIDE EFFECT* (%) Arterial thromboembolism (<10%) Venous thromboembolism (<10%) Other (porphyria cutanea tarda, cutaneous lupus erythematosus - rare) Radiation recall reaction (rare) Rash (>10%; in rare cases may be severe) nolvadex pra que serve novedex xt reviews 2017 nolvadex restart nolvadex 10mg side effects aromasin Constipation (<10%) Nausea, vomiting (>10%) Edema , fluid retention (>10%) Tumour flare (<10%) (rare ↑ calcium early in therapy) Myelosuppression (<1%, usually mild, including ↑ LFTs (<10%, rarely severe) Pancreatitis (rare) Hypersensitivity Hypersensitivity (<10%) Metabolic / Endocrine ↑ Triglycerides (<10%) Musculoskeletal pain (<10%) Secondary malignancy (including endometrial cancer, uterine sarcoma - rare) Depression (<1%) Dizziness (<10%) Optic neuritis (<1%) Paresthesia (<10%) Eye disorders (corneal changes - rare) Retinopathy (<10%) Gastrointestinal Any use of the information is subject, at all times, to CCO’s Terms and Conditions .

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