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Caution should be used in hypovolemic patients, such as those suffering acute myocardial infarction, roxicodone because oxycodone may cause or further aggravate their hypotension .
Caution should also be used in patients with cor pulmonale who have received therapeutic doses of Pharmacodynamics: The relationship between the plasma roxicodone level of oxycodone and the analgesic response will depend on the patient's age, state of health, medical condition and extent of previous opioid treatment .
The minimum effective plasma concentration of roxicodone oxycodone to achieve analgesia will vary widely among patients, especially among patients who have been previously treated with potent agonist opioids .
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